Osteoarthritis score. Samples were histologically evaluated based on the standard grading and staging of OA cartilage histopathology. Evaluation was quantified using the following formula: most degenerated site in the cartilage (grades 1-6, Table 2) × area of degeneration (stages 1-4, Table 3) = OA score (1-24, Table 3). Columns and vertical lines represent mean values and standard deviations for each group, respectively. No significant differences were observed between group C and groups M1 and M2. Significant differences were observed between groups H and C, between groups H and M1 or M2, between groups H and MH1, and between groups M1 or M2 and groups MH1 or MH2. *Significant differences between groups, corresponding to the last column in Table 1. After analysis of variance, least significant differences were used for post hoc testing (Scheffé's method). Mean OA scores were compared and values of * P < 0.05 were considered significant. Groups M1 and MH1: moon jellyfish extract. Groups M2 and MH2: Nomura's jellyfish extract.