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Table 2 Maximal adsorption, affinity constant (K) and area per adsorbed BSA molecule on silica (0.1 mg/ml) or on DODAB covered silica particles in two different media

From: Silica-based cationic bilayers as immunoadjuvants

Particles Maximal adsorption
(molecules m-2)
Affinity Constant
(K, M-1)
Area per adsorbed molecule
(nm2)
SiO2/BSA(i) 4.14 × 1016 1.19 × 109 24.15
SiO2/BSA(ii) 4.75 × 1016 8.19 × 107 21.05
SiO2/DODAB/BSA(i) 7.20 × 1016 5.18 × 107 13.88
SiO2/DODAB/BSA(ii) 3.22 × 1017 8.98 × 108 3.10
SiO2/18 kDa-hsp(ii) 1.12 × 1017 - -
SiO2/DODAB/18 kDa-hsp(ii) 10.00 × 1017 - -
  1. (i) 1 mM NaCl (pH 6.3).
  2. (ii) 5 mM Tris.HCl (pH 7.4).
  3. Final DODAB concentration was 0.05 mM.