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Table 6 Hematological parameters in plasmid-GHRH treated cats with CRF.

From: Gene therapy by electroporation for the treatment of chronic renal failure in companion animals

Assessment

Red Blood

Cells

Hematocrit

Hemoglobin

Mean Red Cell Hemoglobin

Control

Day 0

Average score

n

7.19 ± .4

n = 12

31.68 ± 1.5

n = 13

11.02 ± .5

n = 12

15.44 ± .4

n = 12

 

Day 20

Average score

% change

P-value vs. Day 0

7.72 ± .5

7.3%

P < 0.16

n = 7

32.87 ± 2.0

3.8%

P < 0.30

n = 10

10.75 ± .8

-2.0%

P < 0.35

n = 8

14.27 ± .6

-8.0%

P < 0.06

n = 7

 

Day 40

Average score

% change

P-value vs. Day 0

7.36 ± .6

2.3%

P < 0.41

n = 8

32.17 ± 2.0

1.6%

P < 0.38

n = 10

10.27 ± .9

-7.0%

P < 0.05

n = 9

13.81 ± .7

-11.0%

P < 0.03

n = 8

 

Day 60–75

Average score

% change

P-value vs. Day 0

7.40 ± .3

2.9%

P < 0.47

n = 7

32.10 ± 1.1

1.3%

P < 0.32

n = 7

10.99 ± .5

-0.0%

P < 0.25

n = 7

14.9 ± .6

-4.0%

P < 0.08

n = 7

Treated

Day 0

Average score

n

6.16 ± 0.3

n = 30

27.59 ± 1.1

n = 30

9.65 ± 0.7

n = 30

14.73 ± 0.2

n = 30

 

Day 20

Average score

% change

P-value vs. Day 0

6.71 ± 0.3

9.0%

P < 0.001

n = 29

30.46 ± 1.1

10.4%

P < 0.0009

n = 29

10.11 ± 0.4

4.7%

P < 0.22

n = 29

15.22 ± 0.3

3.3%

P < 0.003

n = 29

 

Day 40

Average score

% change

P-value vs. Day 0

6.35 ± 0.3

3.2%

P < 0.06

n = 26

28.23 ± 1.1

2.3%

P < 0.16

n = 26

9.65 ± 0.3

-0.07%

P < 0.47

n = 26

15.32 ± 0.3

4.0%

P < 0.001

n = 26

 

Day 60–75

Average score

% change

P-value vs. Day 0

6.42 ± 0.4

4.3%

P < 0.02

n = 19

29.18 ± 1.3

5.7%

P < 0.03

n = 20

9.82 ± 0.5

1.6%

P < 0.002

n = 19

15.46 ± 0.4

4.9%

P < 0.004

n = 19

  1. Hematological parameters are significantly improved with plasmid treatment compared to day 0. For cats normal RBC 5.7–10.5 × 106/mm3; normal Ht 38–52%; and normal Hb 9–16 g/dl.