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Table 6 Hematological parameters in plasmid-GHRH treated cats with CRF.

From: Gene therapy by electroporation for the treatment of chronic renal failure in companion animals

Assessment Red Blood Cells Hematocrit Hemoglobin Mean Red Cell Hemoglobin
Control Day 0 Average score n 7.19 ± .4 n = 12 31.68 ± 1.5 n = 13 11.02 ± .5 n = 12 15.44 ± .4 n = 12
  Day 20 Average score % change P-value vs. Day 0 7.72 ± .5 7.3% P < 0.16 n = 7 32.87 ± 2.0 3.8% P < 0.30 n = 10 10.75 ± .8 -2.0% P < 0.35 n = 8 14.27 ± .6 -8.0% P < 0.06 n = 7
  Day 40 Average score % change P-value vs. Day 0 7.36 ± .6 2.3% P < 0.41 n = 8 32.17 ± 2.0 1.6% P < 0.38 n = 10 10.27 ± .9 -7.0% P < 0.05 n = 9 13.81 ± .7 -11.0% P < 0.03 n = 8
  Day 60–75 Average score % change P-value vs. Day 0 7.40 ± .3 2.9% P < 0.47 n = 7 32.10 ± 1.1 1.3% P < 0.32 n = 7 10.99 ± .5 -0.0% P < 0.25 n = 7 14.9 ± .6 -4.0% P < 0.08 n = 7
Treated Day 0 Average score n 6.16 ± 0.3 n = 30 27.59 ± 1.1 n = 30 9.65 ± 0.7 n = 30 14.73 ± 0.2 n = 30
  Day 20 Average score % change P-value vs. Day 0 6.71 ± 0.3 9.0% P < 0.001 n = 29 30.46 ± 1.1 10.4% P < 0.0009 n = 29 10.11 ± 0.4 4.7% P < 0.22 n = 29 15.22 ± 0.3 3.3% P < 0.003 n = 29
  Day 40 Average score % change P-value vs. Day 0 6.35 ± 0.3 3.2% P < 0.06 n = 26 28.23 ± 1.1 2.3% P < 0.16 n = 26 9.65 ± 0.3 -0.07% P < 0.47 n = 26 15.32 ± 0.3 4.0% P < 0.001 n = 26
  Day 60–75 Average score % change P-value vs. Day 0 6.42 ± 0.4 4.3% P < 0.02 n = 19 29.18 ± 1.3 5.7% P < 0.03 n = 20 9.82 ± 0.5 1.6% P < 0.002 n = 19 15.46 ± 0.4 4.9% P < 0.004 n = 19
  1. Hematological parameters are significantly improved with plasmid treatment compared to day 0. For cats normal RBC 5.7–10.5 × 106/mm3; normal Ht 38–52%; and normal Hb 9–16 g/dl.