Table 6 Hematological parameters in plasmid-GHRH treated cats with CRF.
From: Gene therapy by electroporation for the treatment of chronic renal failure in companion animals
| Assessment |
Red Blood Cells | Hematocrit | Hemoglobin | Mean Red Cell Hemoglobin | ||
|---|---|---|---|---|---|---|
| Control | Day 0 |
Average score n |
7.19 ± .4 n = 12 |
31.68 ± 1.5 n = 13 |
11.02 ± .5 n = 12 |
15.44 ± .4 n = 12 |
| Day 20 |
Average score % change P-value vs. Day 0 |
7.72 ± .5 7.3% P < 0.16 n = 7 |
32.87 ± 2.0 3.8% P < 0.30 n = 10 |
10.75 ± .8 -2.0% P < 0.35 n = 8 |
14.27 ± .6 -8.0% P < 0.06 n = 7 | |
| Day 40 |
Average score % change P-value vs. Day 0 |
7.36 ± .6 2.3% P < 0.41 n = 8 |
32.17 ± 2.0 1.6% P < 0.38 n = 10 |
10.27 ± .9 -7.0% P < 0.05 n = 9 |
13.81 ± .7 -11.0% P < 0.03 n = 8 | |
| Day 60–75 |
Average score % change P-value vs. Day 0 |
7.40 ± .3 2.9% P < 0.47 n = 7 |
32.10 ± 1.1 1.3% P < 0.32 n = 7 |
10.99 ± .5 -0.0% P < 0.25 n = 7 |
14.9 ± .6 -4.0% P < 0.08 n = 7 | |
| Treated | Day 0 |
Average score n |
6.16 ± 0.3 n = 30 |
27.59 ± 1.1 n = 30 |
9.65 ± 0.7 n = 30 |
14.73 ± 0.2 n = 30 |
| Day 20 |
Average score % change P-value vs. Day 0 |
6.71 ± 0.3 9.0% P < 0.001 n = 29 |
30.46 ± 1.1 10.4% P < 0.0009 n = 29 |
10.11 ± 0.4 4.7% P < 0.22 n = 29 |
15.22 ± 0.3 3.3% P < 0.003 n = 29 | |
| Day 40 |
Average score % change P-value vs. Day 0 |
6.35 ± 0.3 3.2% P < 0.06 n = 26 |
28.23 ± 1.1 2.3% P < 0.16 n = 26 |
9.65 ± 0.3 -0.07% P < 0.47 n = 26 |
15.32 ± 0.3 4.0% P < 0.001 n = 26 | |
| Day 60–75 |
Average score % change P-value vs. Day 0 |
6.42 ± 0.4 4.3% P < 0.02 n = 19 |
29.18 ± 1.3 5.7% P < 0.03 n = 20 |
9.82 ± 0.5 1.6% P < 0.002 n = 19 |
15.46 ± 0.4 4.9% P < 0.004 n = 19 | |
