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Table 6 Hematological parameters in plasmid-GHRH treated cats with CRF.

From: Gene therapy by electroporation for the treatment of chronic renal failure in companion animals

Assessment Red Blood
Cells
Hematocrit Hemoglobin Mean Red Cell Hemoglobin
Control Day 0 Average score
n
7.19 ± .4
n = 12
31.68 ± 1.5
n = 13
11.02 ± .5
n = 12
15.44 ± .4
n = 12
  Day 20 Average score
% change
P-value vs. Day 0
7.72 ± .5
7.3%
P < 0.16
n = 7
32.87 ± 2.0
3.8%
P < 0.30
n = 10
10.75 ± .8
-2.0%
P < 0.35
n = 8
14.27 ± .6
-8.0%
P < 0.06
n = 7
  Day 40 Average score
% change
P-value vs. Day 0
7.36 ± .6
2.3%
P < 0.41
n = 8
32.17 ± 2.0
1.6%
P < 0.38
n = 10
10.27 ± .9
-7.0%
P < 0.05
n = 9
13.81 ± .7
-11.0%
P < 0.03
n = 8
  Day 60–75 Average score
% change
P-value vs. Day 0
7.40 ± .3
2.9%
P < 0.47
n = 7
32.10 ± 1.1
1.3%
P < 0.32
n = 7
10.99 ± .5
-0.0%
P < 0.25
n = 7
14.9 ± .6
-4.0%
P < 0.08
n = 7
Treated Day 0 Average score
n
6.16 ± 0.3
n = 30
27.59 ± 1.1
n = 30
9.65 ± 0.7
n = 30
14.73 ± 0.2
n = 30
  Day 20 Average score
% change
P-value vs. Day 0
6.71 ± 0.3
9.0%
P < 0.001
n = 29
30.46 ± 1.1
10.4%
P < 0.0009
n = 29
10.11 ± 0.4
4.7%
P < 0.22
n = 29
15.22 ± 0.3
3.3%
P < 0.003
n = 29
  Day 40 Average score
% change
P-value vs. Day 0
6.35 ± 0.3
3.2%
P < 0.06
n = 26
28.23 ± 1.1
2.3%
P < 0.16
n = 26
9.65 ± 0.3
-0.07%
P < 0.47
n = 26
15.32 ± 0.3
4.0%
P < 0.001
n = 26
  Day 60–75 Average score
% change
P-value vs. Day 0
6.42 ± 0.4
4.3%
P < 0.02
n = 19
29.18 ± 1.3
5.7%
P < 0.03
n = 20
9.82 ± 0.5
1.6%
P < 0.002
n = 19
15.46 ± 0.4
4.9%
P < 0.004
n = 19
  1. Hematological parameters are significantly improved with plasmid treatment compared to day 0. For cats normal RBC 5.7–10.5 × 106/mm3; normal Ht 38–52%; and normal Hb 9–16 g/dl.