Table 5 Hematological parameters in plasmid-GHRH treated dogs with CRF.

Control

Day 0

Average score

n

6.29 ± 0.5

n = 9

39.98 ± 2.6

n = 12

13.73 ± 1.0

n = 12

23.13 ± 0.8

n = 10

Day 20

Average score

% change

P-value vs. Day 0

6.43 ± 0.5

2.2%

P < 0.4

n = 6

39.42 ± 1.4

-1.4%

P < 0.2

n = 9

13.89 ± 0.8

1.1%

P < 0.2

n = 7

22.62 ± 0.7

-2.2%

P < 0.05

n = 6

Day 40

Average score

% change

P-value vs. Day 0

5.53 ± 0.4

-12%

P < 0.3

n = 6

37.82 ± 2.2

-5.4%

P < 0.3

n = 6

12.8 ± 1.0

-7.0%

P < 0.4

n = 6

23.08 ± 1.1

-0.2%

P < 0.26

n = 6

Day 60–75

Average score

% change

P-value vs. Day 0

5.69 ± 0.2

-10.0%

P < 0.5

n = 2

39.75 ± 1.2

-0.6%

P < 0.5

n = 2

12.1 ± 2.2

-12.0%

P < 0.5

n = 2

21.1 ± 3.1

-8.8%

P < 0.19

n = 2

Treated

Day 0

Average score

n

4.84 ± 0.3

n = 30

34.95 ± 1.9

n = 30

11.48 ± 0.6

n = 30

23.88 ± 0.2

n = 30

Day 20

Average score

% change

P-value vs. Day 0

5.26 ± 0.3

8.6%

P < 0.02

n = 27

37.4 ± 1.8

7.0%

P < 0.1

n = 27

12.74 ± 0.6

10.9%

P < 0.01

n = 27

24.39 ± 0.3

2.1%

P < 0.02

n = 27

Day 40

Average score

% change

P-value vs. Day 0

5.13 ± 0.3

5.9%

P < 0.09

n = 26

36.73 ± 2.1

5.1%

P < 0.21

n = 26

12.53 ± 0.6

9.1%

P < 0.01

n = 26

24.58 ± 0.3

2.9%

P < 0.001

n = 26

Day 60–75

Average score

% change

P-value vs. Day 0

5.19 ± 0.3

7.1%

P < 0.15

n = 20

37.07 ± 2.2

6%

P < 0.25

n = 20

12.69 ± 0.8

9.1%

P < 0.02

n = 20

24.31 ± 0.4

1.8%

P < 0.1

n = 19