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Table 5 Hematological parameters in plasmid-GHRH treated dogs with CRF.

From: Gene therapy by electroporation for the treatment of chronic renal failure in companion animals

Assessment Red Blood
Cells
Hematocrit Hemoglobin Mean Red Cell Hemoglobin
Control Day 0 Average score
n
6.29 ± 0.5
n = 9
39.98 ± 2.6
n = 12
13.73 ± 1.0
n = 12
23.13 ± 0.8
n = 10
  Day 20 Average score
% change
P-value vs. Day 0
6.43 ± 0.5
2.2%
P < 0.4
n = 6
39.42 ± 1.4
-1.4%
P < 0.2
n = 9
13.89 ± 0.8
1.1%
P < 0.2
n = 7
22.62 ± 0.7
-2.2%
P < 0.05
n = 6
  Day 40 Average score
% change
P-value vs. Day 0
5.53 ± 0.4
-12%
P < 0.3
n = 6
37.82 ± 2.2
-5.4%
P < 0.3
n = 6
12.8 ± 1.0
-7.0%
P < 0.4
n = 6
23.08 ± 1.1
-0.2%
P < 0.26
n = 6
  Day 60–75 Average score
% change
P-value vs. Day 0
5.69 ± 0.2
-10.0%
P < 0.5
n = 2
39.75 ± 1.2
-0.6%
P < 0.5
n = 2
12.1 ± 2.2
-12.0%
P < 0.5
n = 2
21.1 ± 3.1
-8.8%
P < 0.19
n = 2
Treated Day 0 Average score
n
4.84 ± 0.3
n = 30
34.95 ± 1.9
n = 30
11.48 ± 0.6
n = 30
23.88 ± 0.2
n = 30
  Day 20 Average score
% change
P-value vs. Day 0
5.26 ± 0.3
8.6%
P < 0.02
n = 27
37.4 ± 1.8
7.0%
P < 0.1
n = 27
12.74 ± 0.6
10.9%
P < 0.01
n = 27
24.39 ± 0.3
2.1%
P < 0.02
n = 27
  Day 40 Average score
% change
P-value vs. Day 0
5.13 ± 0.3
5.9%
P < 0.09
n = 26
36.73 ± 2.1
5.1%
P < 0.21
n = 26
12.53 ± 0.6
9.1%
P < 0.01
n = 26
24.58 ± 0.3
2.9%
P < 0.001
n = 26
  Day 60–75 Average score
% change
P-value vs. Day 0
5.19 ± 0.3
7.1%
P < 0.15
n = 20
37.07 ± 2.2
6%
P < 0.25
n = 20
12.69 ± 0.8
9.1%
P < 0.02
n = 20
24.31 ± 0.4
1.8%
P < 0.1
n = 19
  1. Hematological parameters are significantly improved with plasmid treatment compared to day 0. For dogs normal RBC 5.5–8.5 × 106/mm3; normal Ht 37–55%; and normal Hb 12–18 g/dl.