Table 5 Hematological parameters in plasmid-GHRH treated dogs with CRF.
From: Gene therapy by electroporation for the treatment of chronic renal failure in companion animals
| Assessment |
Red Blood Cells | Hematocrit | Hemoglobin | Mean Red Cell Hemoglobin | ||
|---|---|---|---|---|---|---|
| Control | Day 0 |
Average score n |
6.29 ± 0.5 n = 9 |
39.98 ± 2.6 n = 12 |
13.73 ± 1.0 n = 12 |
23.13 ± 0.8 n = 10 |
| Day 20 |
Average score % change P-value vs. Day 0 |
6.43 ± 0.5 2.2% P < 0.4 n = 6 |
39.42 ± 1.4 -1.4% P < 0.2 n = 9 |
13.89 ± 0.8 1.1% P < 0.2 n = 7 |
22.62 ± 0.7 -2.2% P < 0.05 n = 6 | |
| Day 40 |
Average score % change P-value vs. Day 0 |
5.53 ± 0.4 -12% P < 0.3 n = 6 |
37.82 ± 2.2 -5.4% P < 0.3 n = 6 |
12.8 ± 1.0 -7.0% P < 0.4 n = 6 |
23.08 ± 1.1 -0.2% P < 0.26 n = 6 | |
| Day 60–75 |
Average score % change P-value vs. Day 0 |
5.69 ± 0.2 -10.0% P < 0.5 n = 2 |
39.75 ± 1.2 -0.6% P < 0.5 n = 2 |
12.1 ± 2.2 -12.0% P < 0.5 n = 2 |
21.1 ± 3.1 -8.8% P < 0.19 n = 2 | |
| Treated | Day 0 |
Average score n |
4.84 ± 0.3 n = 30 |
34.95 ± 1.9 n = 30 |
11.48 ± 0.6 n = 30 |
23.88 ± 0.2 n = 30 |
| Day 20 |
Average score % change P-value vs. Day 0 |
5.26 ± 0.3 8.6% P < 0.02 n = 27 |
37.4 ± 1.8 7.0% P < 0.1 n = 27 |
12.74 ± 0.6 10.9% P < 0.01 n = 27 |
24.39 ± 0.3 2.1% P < 0.02 n = 27 | |
| Day 40 |
Average score % change P-value vs. Day 0 |
5.13 ± 0.3 5.9% P < 0.09 n = 26 |
36.73 ± 2.1 5.1% P < 0.21 n = 26 |
12.53 ± 0.6 9.1% P < 0.01 n = 26 |
24.58 ± 0.3 2.9% P < 0.001 n = 26 | |
| Day 60–75 |
Average score % change P-value vs. Day 0 |
5.19 ± 0.3 7.1% P < 0.15 n = 20 |
37.07 ± 2.2 6% P < 0.25 n = 20 |
12.69 ± 0.8 9.1% P < 0.02 n = 20 |
24.31 ± 0.4 1.8% P < 0.1 n = 19 | |
