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Table 4 Quality of life assessment for GHRH-treated cats.

From: Gene therapy by electroporation for the treatment of chronic renal failure in companion animals

Assessment   Day 0 Day 20 Day 40 Day 60
Overall QOL Average score
n
% change
P-value vs. Day 0
3.0 ± 0.05
n = 28
3.36 ± 0.11
n = 25
12.0%
0.008
3.43 ± 0.14
n = 22
14.39
0.001
3.68 ± 0.19
n = 19
22.81%
0.0009
Body Weight Average score
n
% change
P-value vs. Day 0
3.0 ± 0.0
n = 28
3.0 ± 0.11
n = 18
0.0%
0.5
3.36 ± 0.17
n = 14
11.9%
0.03
3.18 ± 0.21
n = 17
5.88%
0.21
Activity Level Average score
n
% change
P-value vs. Day 0
3.07 ± 0.10
n = 28
3.27 ± 0.13
n = 26
6.44%
0.13
3.66 ± 0.16
n = 22
19.13%
0.002
3.68 ± 0.19
n = 19
19.95%
0.005
Exercise Tolerance Average score
n
% change
P-value vs. Day 0
3.0 ± 0.05
n = 28
3.23 ± 0.08
n = 26
7.69%
0.02
3.26 ± 0.16
n = 21
8.73%
0.06
3.61 ± 0.18
n = 18
20.37%
0.002
Mentation Average score
n
% change
P-value vs. Day 0
3.0 ± 0.09
n = 28
3.46 ± 0.10
n = 26
15.38%
0.002
3.38 ± 0.15
n = 21
12.7%
0.008
3.45 ± 0.14
n = 19
14.91%
0.005
Appetite Average score
n
% change
P-value vs. Day 0
3.07 ± 0.11
n = 28
3.15 ± 0.16
n = 26
2.68%
0.26
3.23 ± 0.16
n = 22
5.07%
0.10
3.26 ± 0.13
n = 19
6.24%
0.04
Thirst Average score
n
% change
P-value vs. Day 0
3.07 ± 0.07
n = 28
3.12 ± 0.08
n = 26
1.43%
0.36
3.19 ± 0.13
n = 21
3.88%
0.27
3.0 ± 0.08
n = 19
-2.33%
0.36
Urination Frequency Average score
n
% change
P-value vs. Day 0
3.04 ± 0.06
n = 28
3.08 ± 0.08
n = 26
1.36%
0.36
3.05 ± 0.05
n = 22
0.32%
0.5
3.0 ± 0.0
n = 19
-1.17%
0.29
Bowel Movement Frequency Average score
n
% change
P-value vs. Day 0
2.93 ± 0.05
n = 28
2.92 ± 0.09
n = 26
-0.19%
0.5
3.0 ± 0.0
n = 22
2.44%
0.08
3.0 ± 0.0
n = 19
2.44%
0.08
Diarrhea Frequency Average score
n
% change
P-value vs. Day 0
3.0 ± 0.0
n = 28
3.04 ± 0.07
n = 26
1.28%
0.29
3.0 ± 0.0
n = 22
0.0%
NS
3.0 ± 0.0
n = 19
0.0%
NS
Vomiting Frequency Average score
n
% change
P-value vs. Day 0
3.07 ± 0.05
n = 28
3.04 ± 0.07
n = 26
-1.07%
0.33
3.0 ± 0.0
n = 22
-2.33%
0.08
3.05 ± 0.05
n = 19
-0.61%
0.29
  1. Abbreviations: NS, not significant Quality of life parameters from day 0 to day 60 of study where 1 = significantly decreased, 2 = decreased, 3 = no change, 4 = increased and 5 = significantly increased. For each parameter, data are presented as average ± SEM. Percentage changes over baseline values, as well as P value versus baseline values is included for each parameter at each time point.