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Table 4 Quality of life assessment for GHRH-treated cats.

From: Gene therapy by electroporation for the treatment of chronic renal failure in companion animals

Assessment

 

Day 0

Day 20

Day 40

Day 60

Overall QOL

Average score

n

% change

P-value vs. Day 0

3.0 ± 0.05

n = 28

3.36 ± 0.11

n = 25

12.0%

0.008

3.43 ± 0.14

n = 22

14.39

0.001

3.68 ± 0.19

n = 19

22.81%

0.0009

Body Weight

Average score

n

% change

P-value vs. Day 0

3.0 ± 0.0

n = 28

3.0 ± 0.11

n = 18

0.0%

0.5

3.36 ± 0.17

n = 14

11.9%

0.03

3.18 ± 0.21

n = 17

5.88%

0.21

Activity Level

Average score

n

% change

P-value vs. Day 0

3.07 ± 0.10

n = 28

3.27 ± 0.13

n = 26

6.44%

0.13

3.66 ± 0.16

n = 22

19.13%

0.002

3.68 ± 0.19

n = 19

19.95%

0.005

Exercise Tolerance

Average score

n

% change

P-value vs. Day 0

3.0 ± 0.05

n = 28

3.23 ± 0.08

n = 26

7.69%

0.02

3.26 ± 0.16

n = 21

8.73%

0.06

3.61 ± 0.18

n = 18

20.37%

0.002

Mentation

Average score

n

% change

P-value vs. Day 0

3.0 ± 0.09

n = 28

3.46 ± 0.10

n = 26

15.38%

0.002

3.38 ± 0.15

n = 21

12.7%

0.008

3.45 ± 0.14

n = 19

14.91%

0.005

Appetite

Average score

n

% change

P-value vs. Day 0

3.07 ± 0.11

n = 28

3.15 ± 0.16

n = 26

2.68%

0.26

3.23 ± 0.16

n = 22

5.07%

0.10

3.26 ± 0.13

n = 19

6.24%

0.04

Thirst

Average score

n

% change

P-value vs. Day 0

3.07 ± 0.07

n = 28

3.12 ± 0.08

n = 26

1.43%

0.36

3.19 ± 0.13

n = 21

3.88%

0.27

3.0 ± 0.08

n = 19

-2.33%

0.36

Urination Frequency

Average score

n

% change

P-value vs. Day 0

3.04 ± 0.06

n = 28

3.08 ± 0.08

n = 26

1.36%

0.36

3.05 ± 0.05

n = 22

0.32%

0.5

3.0 ± 0.0

n = 19

-1.17%

0.29

Bowel Movement Frequency

Average score

n

% change

P-value vs. Day 0

2.93 ± 0.05

n = 28

2.92 ± 0.09

n = 26

-0.19%

0.5

3.0 ± 0.0

n = 22

2.44%

0.08

3.0 ± 0.0

n = 19

2.44%

0.08

Diarrhea Frequency

Average score

n

% change

P-value vs. Day 0

3.0 ± 0.0

n = 28

3.04 ± 0.07

n = 26

1.28%

0.29

3.0 ± 0.0

n = 22

0.0%

NS

3.0 ± 0.0

n = 19

0.0%

NS

Vomiting Frequency

Average score

n

% change

P-value vs. Day 0

3.07 ± 0.05

n = 28

3.04 ± 0.07

n = 26

-1.07%

0.33

3.0 ± 0.0

n = 22

-2.33%

0.08

3.05 ± 0.05

n = 19

-0.61%

0.29

  1. Abbreviations: NS, not significant Quality of life parameters from day 0 to day 60 of study where 1 = significantly decreased, 2 = decreased, 3 = no change, 4 = increased and 5 = significantly increased. For each parameter, data are presented as average ± SEM. Percentage changes over baseline values, as well as P value versus baseline values is included for each parameter at each time point.
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BMC Biotechnology

ISSN: 1472-6750

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