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Table 4 Quality of life assessment for GHRH-treated cats.

From: Gene therapy by electroporation for the treatment of chronic renal failure in companion animals

Assessment   Day 0 Day 20 Day 40 Day 60
Overall QOL Average score n % change P-value vs. Day 0 3.0 ± 0.05 n = 28 3.36 ± 0.11 n = 25 12.0% 0.008 3.43 ± 0.14 n = 22 14.39 0.001 3.68 ± 0.19 n = 19 22.81% 0.0009
Body Weight Average score n % change P-value vs. Day 0 3.0 ± 0.0 n = 28 3.0 ± 0.11 n = 18 0.0% 0.5 3.36 ± 0.17 n = 14 11.9% 0.03 3.18 ± 0.21 n = 17 5.88% 0.21
Activity Level Average score n % change P-value vs. Day 0 3.07 ± 0.10 n = 28 3.27 ± 0.13 n = 26 6.44% 0.13 3.66 ± 0.16 n = 22 19.13% 0.002 3.68 ± 0.19 n = 19 19.95% 0.005
Exercise Tolerance Average score n % change P-value vs. Day 0 3.0 ± 0.05 n = 28 3.23 ± 0.08 n = 26 7.69% 0.02 3.26 ± 0.16 n = 21 8.73% 0.06 3.61 ± 0.18 n = 18 20.37% 0.002
Mentation Average score n % change P-value vs. Day 0 3.0 ± 0.09 n = 28 3.46 ± 0.10 n = 26 15.38% 0.002 3.38 ± 0.15 n = 21 12.7% 0.008 3.45 ± 0.14 n = 19 14.91% 0.005
Appetite Average score n % change P-value vs. Day 0 3.07 ± 0.11 n = 28 3.15 ± 0.16 n = 26 2.68% 0.26 3.23 ± 0.16 n = 22 5.07% 0.10 3.26 ± 0.13 n = 19 6.24% 0.04
Thirst Average score n % change P-value vs. Day 0 3.07 ± 0.07 n = 28 3.12 ± 0.08 n = 26 1.43% 0.36 3.19 ± 0.13 n = 21 3.88% 0.27 3.0 ± 0.08 n = 19 -2.33% 0.36
Urination Frequency Average score n % change P-value vs. Day 0 3.04 ± 0.06 n = 28 3.08 ± 0.08 n = 26 1.36% 0.36 3.05 ± 0.05 n = 22 0.32% 0.5 3.0 ± 0.0 n = 19 -1.17% 0.29
Bowel Movement Frequency Average score n % change P-value vs. Day 0 2.93 ± 0.05 n = 28 2.92 ± 0.09 n = 26 -0.19% 0.5 3.0 ± 0.0 n = 22 2.44% 0.08 3.0 ± 0.0 n = 19 2.44% 0.08
Diarrhea Frequency Average score n % change P-value vs. Day 0 3.0 ± 0.0 n = 28 3.04 ± 0.07 n = 26 1.28% 0.29 3.0 ± 0.0 n = 22 0.0% NS 3.0 ± 0.0 n = 19 0.0% NS
Vomiting Frequency Average score n % change P-value vs. Day 0 3.07 ± 0.05 n = 28 3.04 ± 0.07 n = 26 -1.07% 0.33 3.0 ± 0.0 n = 22 -2.33% 0.08 3.05 ± 0.05 n = 19 -0.61% 0.29
  1. Abbreviations: NS, not significant Quality of life parameters from day 0 to day 60 of study where 1 = significantly decreased, 2 = decreased, 3 = no change, 4 = increased and 5 = significantly increased. For each parameter, data are presented as average ± SEM. Percentage changes over baseline values, as well as P value versus baseline values is included for each parameter at each time point.