TY - JOUR AU - Waite, Carolyn L. AU - Sparks, Sarah M. AU - Uhrich, Kathryn E. AU - Roth, Charles M. PY - 2009 DA - 2009/04/23 TI - Acetylation of PAMAM dendrimers for cellular delivery of siRNA JO - BMC Biotechnology SP - 38 VL - 9 IS - 1 AB - The advancement of gene silencing via RNA interference is limited by the lack of effective short interfering RNA (siRNA) delivery vectors. Rational design of polymeric carriers has been complicated by the fact that most chemical modifications affect multiple aspects of the delivery process. In this work, the extent of primary amine acetylation of generation 5 poly(amidoamine) (PAMAM) dendrimers was studied as a modification for the delivery of siRNA to U87 malignant glioma cells. SN - 1472-6750 UR - https://doi.org/10.1186/1472-6750-9-38 DO - 10.1186/1472-6750-9-38 ID - Waite2009 ER -