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Table 2 Control of B. annulatus infestations in cattle vaccinated with the recombinant Ba86 and Bm86 preparations.

From: Vaccination with recombinant Boophilus annulatus Bm86 ortholog protein, Ba86, protects cattle against B. annulatus and B. microplus infestations

 

Boophilus annulatus(Mission, TX strain)

 

Percent reduction (vaccinated/control)b

Ec

Experimental group a

DT

DW

DO

DF

 

Ba86 (Israeli strain)

71%

(217 ± 128)*

8%

(285 ± 17)

22%

(89 ± 10)*

25%

(0.3 ± 0.1)*

83.0%

Bm86 (Gavac; Cuban Camcord strain)

95%

(34 ± 33)*

54%

(141 ± 59)*

66%

(39 ± 17)*

75%

(0.1 ± 0.1)*

99.6%

Bm86 (Mozambique strain)

99%

(4 ± 2)*

23%

(240 ± 62)

25%

(85 ± 24)*

50%

(0.2 ± 0.1)*

99.6%

Adjuvant/saline control

750 ± 127

310 ± 52

114 ± 8

0.4 ± 0.04

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  1. aCattle were randomly assigned to experimental groups (N = 5), vaccinated and challenged with B. microplus and B. annulatus larvae.
  2. bThe percent reduction was calculated with respect to the control group: DT, % reduction in tick infestation; DW, % reduction in tick weight; DO, % reduction in oviposition; DF, % reduction in egg fertility. In parenthesis are shown the average ± S.E. for adult female tick number, tick weight, oviposition and egg fertility and were compared by Student's t-test with unequal variance between vaccinated and control groups. (*P < 0.05).
  3. cVaccine efficacy (E) was calculated as 100 [l-(CRT × CR0 × CRF)], where CRT, CRO and CRF are the reduction in the number of adult female ticks, oviposition and egg fertility as compared to the control group, respectively.
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BMC Biotechnology

ISSN: 1472-6750

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