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Table 1 Control of B. microplus infestations in cattle vaccinated with the recombinant Ba86 and Bm86 preparations.

From: Vaccination with recombinant Boophilus annulatus Bm86 ortholog protein, Ba86, protects cattle against B. annulatus and B. microplus infestations

  Boophilus microplus(Susceptible; Mexico strain)
  Percent reduction (vaccinated/control)b Ec
Experimental group a DT DW DO DF  
Ba86 (Israeli strain) 40%
(506 ± 96)*
15%
(252 ± 14)*
5%
(104 ± 11)
50%
(0.2 ± 0.04)*
71.5%
Bm86 (Gavac; Cuban Camcord strain) 59%
(348 ± 99)*
15%
(253 ± 9)*
28%
(78 ± 8)*
50%
(0.2 ± 0.03)*
85.2%
Bm86 (Mozambique strain) 22%
(655 ± 172*)
17%
(245 ± 14)*
24%
(83 ± 11)*
50%
(0.2 ± 0.04)*
70.4%
Adjuvant/saline control 841 ± 94 297 ± 19 109 ± 10 0.4 ± 0.0 ---
  1. aCattle were randomly assigned to experimental groups (N = 5), vaccinated and challenged with B. microplus and B. annulatus larvae.
  2. bThe percent reduction was calculated with respect to the control group: DT, % reduction in tick infestation; DW, % reduction in tick weight; DO, % reduction in oviposition; DF, % reduction in egg fertility. In parenthesis are shown the average ± S.E. for adult female tick number, tick weight, oviposition and egg fertility and were compared by Student's t-test with unequal variance between vaccinated and control groups. (*P < 0.05).
  3. cVaccine efficacy (E) was calculated as 100 [l-(CRT × CR0 × CRF)], where CRT, CRO and CRF are the reduction in the number of adult female ticks, oviposition and egg fertility as compared to the control group, respectively.