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Table 1 Control of B. microplus infestations in cattle vaccinated with the recombinant Ba86 and Bm86 preparations.

From: Vaccination with recombinant Boophilus annulatus Bm86 ortholog protein, Ba86, protects cattle against B. annulatus and B. microplus infestations

 

Boophilus microplus(Susceptible; Mexico strain)

 

Percent reduction (vaccinated/control)b

Ec

Experimental group a

DT

DW

DO

DF

 

Ba86 (Israeli strain)

40%

(506 ± 96)*

15%

(252 ± 14)*

5%

(104 ± 11)

50%

(0.2 ± 0.04)*

71.5%

Bm86 (Gavac; Cuban Camcord strain)

59%

(348 ± 99)*

15%

(253 ± 9)*

28%

(78 ± 8)*

50%

(0.2 ± 0.03)*

85.2%

Bm86 (Mozambique strain)

22%

(655 ± 172*)

17%

(245 ± 14)*

24%

(83 ± 11)*

50%

(0.2 ± 0.04)*

70.4%

Adjuvant/saline control

841 ± 94

297 ± 19

109 ± 10

0.4 ± 0.0

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  1. aCattle were randomly assigned to experimental groups (N = 5), vaccinated and challenged with B. microplus and B. annulatus larvae.
  2. bThe percent reduction was calculated with respect to the control group: DT, % reduction in tick infestation; DW, % reduction in tick weight; DO, % reduction in oviposition; DF, % reduction in egg fertility. In parenthesis are shown the average ± S.E. for adult female tick number, tick weight, oviposition and egg fertility and were compared by Student's t-test with unequal variance between vaccinated and control groups. (*P < 0.05).
  3. cVaccine efficacy (E) was calculated as 100 [l-(CRT × CR0 × CRF)], where CRT, CRO and CRF are the reduction in the number of adult female ticks, oviposition and egg fertility as compared to the control group, respectively.
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BMC Biotechnology

ISSN: 1472-6750

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