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Table 2 Summary of transgenic animals producing BChE/hSA fusion protein

From: Substantially improved pharmacokinetics of recombinant human butyrylcholinesterase by fusion to human serum albumin

Transgenic animal

Animal ID

Generation

Sex

Transgene copy number

Integration site

Expression in milk (g/liter)*

Mouse

307-1

F0

F

~40

ND

0.27

 

307-1A2

F1

F

1–2

ND

0.40

 

307-1A7

F1

F

8–10

ND

0.41

 

307-1A7A2

F2

F

8–10

ND

0.24

 

307-1A7A4

F2

F

1–2

ND

0.41

Goat

2176

F0

F

18–28

2

0.06

 

2177

F0

F

6–10

1–2

1.10

 

2178

F0

F

18–28

2–3

0.07

 

2229

F0

F

10–14

1–2

0.07

 

2231

F0

F

10–14

1–2

0.04

 

2232

F0

F

10–14

1–2

0.09

 

2233

F0

F

10–14

1–2

0.08

 

2234

F0

F

10–14

1–2

0.35

 

2236

F0

F

10–14

1–2

0.10

 

2237

F0

F

10–14

1–2

0.23

 

2238

F0

F

10–14

1–2

0.09

 

2239

F0

F

10–14

1–2

0.11

  1. *The concentrations for expression of BChE/hSA, estimated by densitometry where 720 units = 1 mg of purified plasma huBChE. [29], were the average of two independent assays. ND = not determined.