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Figure 9 | BMC Biotechnology

Figure 9

From: Impact of point-mutations on the hybridization affinity of surface-bound DNA/DNA and RNA/DNA oligonucleotide-duplexes: Comparison of single base mismatches and base bulges

Figure 9

Comparison of DNA/DNA and RNA/DNA mismatch hybridization signals – statistical analysis. (A) MM-type related influence in DNA/DNA oligonucleotide duplexes. The positional influence was eliminated by subtraction of the moving average MM profile. Subsequent normalization was performed by division through the mean hybridization signal of the particular MM profile. (B) MM-type related influence in RNA/DNA oligonucleotide duplexes. Hybridization signal differences between the pairs of RNA/DNA- and analog DNA/DNA-duplexes are shown in Additional file 7.

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BMC Biotechnology

ISSN: 1472-6750

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