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Figure 1 | BMC Biotechnology

Figure 1

From: Impact of point-mutations on the hybridization affinity of surface-bound DNA/DNA and RNA/DNA oligonucleotide-duplexes: Comparison of single base mismatches and base bulges

Figure 1

Design of the experiment. A comprehensive set of point-mutated probes is derived from a common probe sequence motif which is complementary to the target sequence. Probe sequences are shown for the first two defect positions only. To enhance quantitative analysis probe sequences are arranged on the microarray as a compact feature block. Hybridization signals from hybridization with the target sequence are plotted versus defect position. The defect profile shows relative hybridization affinities depending on the probe sequence motif, defect type and defect position.

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BMC Biotechnology

ISSN: 1472-6750

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