Table 1 The pharmacokinetic parameters of HCPT or HCPT-loaded nanoparticles after IV administration at a single dose of 12 mg/kg in rabbit
From: Hydroxycamptothecin-loaded nanoparticles enhance target drug delivery and anticancer effect
t 1/2 (h) | Cmax (μg/L) | Tmax(h) | Vd(L) | AUC(μg · h/L) | |
|---|---|---|---|---|---|
HCPT | 4.5 | 2627.8 | 0 | 7.3 | 2459.0 |
HCPT/PEG-PBLG | 10.1 | 1513.5 | 1 | 20 | 2175.9 |