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Table 1 Mean particle sizes (nm) obtained for the DNA molecules at three (5.0, 7.5 and 10.0) carrier:DNA mass ratios. The values shown are usually derived form the average of 2 measurements, and SD between the measurements was <5% (not shown). NS: No stable measurements were taken for these samples. The zeta potential of the particles were >30 mV in all cases (not shown).

From: Effects of size and topology of DNA molecules on intracellular delivery with non-viral gene carriers

 

Circular DNA

Linear DNA

PCR DNA

 

5.0

7.5

10.0

5.0

7.5

10.0

5.0

7.5

10.0

PEI

337

188

159

735

710

772

518

414

273

PLL-PA

169

124

106

354

388

338

104

99

103

Lipo

758

964

1002

NS

1406

421

NS

NS

NS