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Table 3 Effect of RIN and probe sensitivity to RNA degradation on assay sensitivity. The percent sensitivity for a false positive rate of 10% [and 95% Confidence Interval] is reported for liver selective probe sets that significantly decrease in response to RNA degradation (LS_DEC), all liver selective probe sets (LS_ALL), and liver selective probe sets that are invariant to RNA degradation (LS_INV).

From: Characterization of the effect of sample quality on high density oligonucleotide microarray data using progressively degraded rat liver RNA

Fold change RIN group LS_DEC LS_ALL LS_INV
1.5 9.5 97.2 [85.8, 99.7] 92.9 [88.2, 96.1] 100 [94.0, 100]
  8 92.4 [78.7, 98.1] 92.0 [87.5, 95.2] 100 [93.6, 100]
  7 72.7 [55.2, 85.9] 88.7 [82.0, 93.4] 100 [90.3, 100]
  6 68.4 [51, 82.5] 88.3 [82.9, 92.4] 100 [84.5, 100]
2 9.5 99.2 [90.7, 100] 96.3 [93.3, 98.1] 100a
  8 94.3 [82.6, 98.7] 94.7 [91.6, 96.8] 99.9 [80.3, 100]
  7 84.2 [68.7, 93.6] 93.8 [89.4, 96.7] 100 [39.5, 100]
  6 83.6 [68.3, 93.1] 93.3 [89.3, 96.0] 100 [79.7, 100]
4 9.5 99.0 [89.3, 100] 96.9 [94.5, 98.4] 100a
  8 96.4 [85.8, 99.4] 95.7 [93.1, 97.5] 100a
  7 87.8 [74.1, 95.4] 95.3b 100a
  6 87.6 [74.2, 95.2] 94.6 [91.6, 96.7] 100a
  1. aNo CI (for perfect discrimination, data cannot be fitted to a ROC curve)
  2. bValue interpolated from empirical data using Weibull cumulative discrimination function