Figure 8

Recombinant DI binds purified aPL derived from patients with APS. Results are expressed as percentage binding of a standard APS IgG sample known to bind DI, whole β₂GPI and CL. IgG was purified from 21 APS patients, 14 SLE patients and 9 normal controls. 20 μg/ml of IgG of each individual patient sample was tested for binding to DI and compared to the standard. Binding to DI was significantly greater in the APS group compared to SLE disease control and normal control groups (Student's t-test analysis (paired, 2-tailed) – APS versus SLE, **p < 0.005; APS versus normal controls, **p < 0.005; SLE versus normal controls p = 0.2).