NERVE: New Enhanced Reverse Vaccinology Environment

Table 2 Test of NERVE settings on another dataset including 6 proteomes.

Pathogen	Strain	Known protective antigens (non cytoplasmic, ≤2 TMs)	Primary accession numbers (Uniprot database)	References
Staphylococcus aureus	MW2	Spa, PBP2A, ClfA, collagen-binding, fibronectin-binding, enterotoxin A, alpha-toxin	Q8NXT0 Q8NWP5 P0A0L1 Q8NUH0 Q8NUU7 Q8NX49 Q8NXJ1	[37–39]
Neisseria gonorrhoeae	ATCC 700825	PorB, TbpA, TbpB	Q5F5V7 Q5F6Q4 Q5F6Q3	[40,41]
Streptococcus pyogenes M1	SF370	Spy0128, Spy0130, Spy0843, Spy1357, Spy1274, Spy1390, Spy0416, Spy2010, Spy2018	P60811 Q7DAL7 Q99ZD7 Q9A0C0 Q9A180 Q9A1S0 Q9A1S2 P58099 Q99XV0	[42]
Campylobacter jejuni	NCTC 11168	FlaA, cjaA	P56963 Q9PNV7	[43,44]
Helicobacter pylori	J99	CagA, VacA, NAP	Q9ZKW5 Q9ZLT1 Q9ZMJ1	[45]
Chlamydia pneumoniae	CWL029	MOMP, Pmp2, ArtJ, HtrA, OmpH-like	P27455 Q9Z3A1 Q9Z869 Q9Z6T0 Q9Z8N7	[46,46]

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