Figure 2

Flow-chart of NERVE working process. Amino acid sequences from the whole bacterial proteome undergo six analytical steps: prediction of subcellular localization (1), calculation of probability of being adhesin (2), identification of TM domains (3), comparison to the proteome of Homo sapiens (4) and to that of a pathogen selected by the user (5), assignment of a putative function (6). Each of these steps stores data mined in an SQL database. After filtering and ranking, the best VCs are presented in a user-friendly html table (see figure 1 and Results and Discussion for details).