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Figure 1 | BMC Biotechnology

Figure 1

From: CpG-island fragments from the HNRPA2B1/CBX3genomic locus reduce silencing and enhance transgene expression from the hCMV promoter/enhancer in mammalian cells

Figure 1

The human HNRPA2B1/CBX3 (RNP) locus and constructs used in EGFP and EPO expression studies. A. Organisation of the RNP genomic locus. The figure indicates the locations of the divergent promoters (arrows), the exons (black boxes) and the 8.0 kb Hind III fragment that includes the 3 kb unmethylated CpG island. B. EGFP and EPO expression constructs. All constructs carried the Neor gene preceded by the SV40 promoter for selection of stable transfectants of CHO-K1 cells.

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BMC Biotechnology

ISSN: 1472-6750

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