Figure 3

Amino acid sequences of CDRs of binding antibodies. Amino acid sequences of VH and VL CDRs of antibodies selected from the Nkuku library. Asterisks (*) denote clones which have high probability of having been derived from the portion of the library into which synthetic CDR3s were introduced. The entire H chain of clone C31 was absent, but the fragment bound to CMV particles in ELISA (not shown). The antigens recognised by each of the individual clones are indicated in the figure. Dots (.) indicate spaces introduced to align sequences, x denotes ambiguous bases. (Genbank accession numbers: Lca12, AY366194; Hca12, AY366195; C6, 366196; E8-10, AY366197; E8-3, AY366198; H2, AY366199; C23, AY366200; C24, AY366201; C26, AY366202; C29, AY366203; C31, AY366204)