Table 1 Local and systemic IL-1Ra after administration of IL-1Ra-producing B. subtilis

Mouse

peritoneal cavity

0 h

-

-

3 h

++

+

6 h

+

-

24 h

-

-

Rat

small intestine

0 h

-

-

3 h

++

-

4 h

+ (B: 149.4 μg)

-

6 h

+/-

-

8 h

+/- (B: 16.5 μg)

-

24 h

-

n.t.

large intestine

0 h

-

-

2 h

n.t.

++ (B: 0.6–1.3 μg/ml)

3 h

+++

n.t.

4 h

+++

++ (B: 0.5–1.9 μg/ml)

6 h

++

+

8 h

++

+ (B: 0.1–0.4 μg/ml)

24 h

+

n.t.

Rabbit

large intestine

0 h

-

- (B/E: 0 μg/ml)

0.5 h

n.t.

+ (B: 0.2–0.4 μg/ml)

1 h

n.t.

++ (B/E: 0.2–1.2 μg/ml)

2 h

n.t.

++ (B/E: 0.6–1.6 μg/ml)

3 h

n.t.

++ (B: 0.6–2.0 μg/ml)

4 h

++

++ (B/E: 0.4–2.1 μg/ml)

6 h

n.t.

++ (B/E: 0.3–0.9 μg/ml)

8 h

++

++ (E: 0.6–2.4 μg/ml)

24 h

n.t.

+ (B: 0.3 μg/ml)