Figure 4From: Glycerol restores heat-induced p53-dependent apoptosis of human glioblastoma cells bearing mutant p53A schema showing restoration of normal p53 function by glycerol in mp53. Serine 15 of wtp53 and mp53 are phosphorylated by the PI3-K family. Glycerol is effective in inducing conformational change of misfolding mp53 and renaturing mp53 to wtp53 which mediates heat sensitivity through bax expression.Back to article page