Figure 2

Inflammatory microscopic score of experimental colitis and histopathology of intestinal changes between all groups. Macroscopic score of mice treated with DSS that received the different L. lactis strains compared to the DSS group without any specific administration (A). Histological activity index (HAI) was obtained from the colonic tissues stained by H&E. Bars represent the mean ± SD of 6 mice per group of two independent experiments. Asterisks represent statistical significance (**p < 0.01 or ***p < 0.0001). All groups are statistically significant to the control group (***p < 0.0001). Representative photos obtained from the proximal colon of a mouse from control group: Control group (B), DSS group (C), and the groups of mice treated with DSS that received L. lactis MG1363 (D) L. lactis MG1363 pValac:il-10 (E) Proximal colon of diseased mice that received the L. lactis MG1363 FnBPA + (F) or L. lactis MG1363 FnBPA + pValac:il-10 (G). The bar on each image represents 100 μm. The short white arrows show the depletion of goblet cells; the long white arrow, intense oedema in the submucosa; the short black arrow, crypt abscesses; and the long black arrow, inflammatory infiltrate (especially of macrophages).