TY - JOUR AU - Lu, Xiao-Yun AU - Li, Ming-Chuan AU - Zhu, Xin-Liang AU - Fan, Fan AU - Wang, Lei-Lei AU - Ma, Jian-Gang PY - 2014 DA - 2014/01/18 TI - Microbial synthesized biodegradable PHBHHxPEG hybrid copolymer as an efficient intracellular delivery nanocarrier for kinase inhibitor JO - BMC Biotechnology SP - 4 VL - 14 IS - 1 AB - Protein Kinases are key regulators of cell function and play essential roles in the occurrence and development of many human diseases. Many kinase inhibitors have been used for molecular targeted treatment of those diseases such as cancer and inflammation. However, those highly hydrophobic kinase inhibitors shared the common features of poor bioavailability and limited in vivo half-life, which strongly impeded their practical applications. Our previous study demonstrated that microbial synthesized biodegradable polyester poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx), a member of polyhydroxyalkanoates (PHAs) family, could serve as a promising delivery nanocarrier for those hydrophobic kinase inhibitors. Recently, a novel natural synthesized hybrid copolymer, PEG200 end-capped PHBHHx (PHBHHxPEG) was produced by Aeromonas hydrophila fermentation. In this study, the novel PHBHHxPEG NPs were prepared and investigated to serve as intracellular delivery nanocarriers for sustained release of hydrophobic kinase inhibitors. SN - 1472-6750 UR - https://doi.org/10.1186/1472-6750-14-4 DO - 10.1186/1472-6750-14-4 ID - Lu2014 ER -