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Figure 7 | BMC Biotechnology

Figure 7

From: Accuracy and efficiency define Bxb1 integrase as the best of fifteen candidate serine recombinases for the integration of DNA into the human genome

Figure 7

Hypothetical mechanism for the origin of the G418rgancyclovirr, attR-, attL-clones generated by the serine integrases during integration reactions. The figure shows a two step model for the origin of the GANCr Neor attL-attR-clones arising during the integration experiments. A illustrates the first step in the model; the deletion of the HyTK gene and B illustrates the second step; the integration of the CCAGneo gene. Further details are discussed in the text.

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