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Table 2 Knockout strategies for BDO overproduction identified in this work

From: Dynamic strain scanning optimization: an efficient strain design strategy for balanced yield, titer, and productivity. DySScO strategy for strain design

BDO Strains

YZ4

YZ5

YIM1260

Growth rate (hr-1)

0.3

0.35

0.3

Product yield

0.52

0.51

0.52

(mol/mol glc)

Knockouts

ALCD2x

ALCD2x

ALCD2x

 

PFL

PFL

PFL

 

PGI

 

MDH

 

TKT2

 

LDH_D

  1. The knockouts are listed by their reaction names in the iAF1260 genome-scale model of E. coli metabolism.
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BMC Biotechnology

ISSN: 1472-6750

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