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Figure 5 | BMC Biotechnology

Figure 5

From: Monoclonal antibody humanness score and its applications

Figure 5

Associating immunogenicity and humanness score of therapeutic antibodies. (A) The immunogenicity (percent of patients that had antibodies against the therapeutic antibody itself) and T20 score of 65 therapeutic antibodies (full-length heavy chains on the left, kappa light chains on the right) were graphed together, and Pearson correlations were calculated (red-dashed line; R2). P-values are one-sided t-tests. (B) The same data from (A) is shown with the antibody type indicated by different colors. Trend lines for each group are shown in their respective color. The arrow points to the humanized antibody daclizumab that is referenced in the main text. (C) The black bars are the average ± SD immunogenicity of the indicated group of antibodies; the gray bars show the average ± SD T20 score.

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