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Table 5 Variation of the cloning outcome depending on different nuclear donor cell sources

From: Factors influencing the efficiency of generating genetically engineered pigs by nuclear transfer: multi-factorial analysis of a large data set

Cell source1

Fusion rate (%)

Chance for pregnancy

Chance for delivery

Cloning efficiency (%)

No. of live cloned piglets

No. of healthy cloned piglets

MSC

93.0

1.1

5.3

3.5

1.6

0.3

PF

80.2*

0.7

4.0

4.1

2.0

0.5

FF

89.1*

1.8

3.7*

4.4

3.4*

1.9*

KC

90.4*

1.3

2.9*

3.8

3.4*

1.4*

  1. Mesenchymal stem cells (MSC) were used as the reference category. For details on the statistical analysis and definition of the cloning benchmarks listed, please see Methods.
  2. * Statistically significant differences (p < 0.05).
  3. 1 Mesenchymal stem cells (MSC), postnatal fibroblasts (PF), fetal fibroblasts (FF), and kidney cells (KC).
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BMC Biotechnology

ISSN: 1472-6750

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