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Table 1 Temperature sensitivity of A/Singapore and B/Vienna viruses in CR.pIX cells

From: Live attenuated influenza viruses produced in a suspension process with avian AGE1.CR.pIX cells

Maximum TCID50titers [virions/mL]*

33°C

37°C

40°C

Before adaptation to CR.pIX cells

   

A/Singapore

1.3 × 108

0

-#

B/Vienna

1.8 × 105

0

-

After adaptation to CR.pIX cells

   

A/Singapore

2.4 × 108

1.8 × 106

0

B/Vienna

3.2 × 106

0

-

  1. *Maximum titers of CR.pIX cells infected in T-flasks at a CCI of 2 × 106 cells/mL and with 1 × 10-6 units trypsin per cell.
  2. #not determined.
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BMC Biotechnology

ISSN: 1472-6750

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