Intra-parenchymal administration of AdCMV-EGFP in mouse and rat pancreas. (A-F) Paraffin sections of the pancreas of CD1 mice injected with (A, B) 109 Pfu AdCMV-EGFP analysed on day 4 after injection, (C-F) with 2 x 109 Pfu AdCMV-EGFP analysed (C-D) on day 7 or (E-F) day 9 after injection. (A, C, E) Immunohistochemical staining for EGFP in red and DNA in blue. (B, D, F) Haematoxylin-eosin staining. (G-N) Comparison of intra-parenchymal injection of 5 × 109 Pfu AdCMV-EGFP in (G, I, K, M) immune-competent (Wistar) rats and (H, J, L, N) immune-deficient (RNU) rats, analysed (G-J) on day 4 and (K-N) day 7 after injection. (G-H, K-L) Immunohistochemical staining for EGFP in red and DNA in blue. (I-J, M-N) Haematoxylin-eosin staining.