Figure 6
From: M cell targeting by a Claudin 4 targeting peptide can enhance mucosal IgA responses
Comparison of intranasal and subcutaneous immunization protocols. Analysis of antibody responses to intranasal versus subcutaneous immunization shows similar Th2 dominance in the IgG isotype response. A, Immunization protocols showing the difference between the multiple dose intranasal administration and single dose subcutaneous alum administration. B, Differences in mucosal response to immunization showing the absence of mucosal responses in subcutaneously immunized mice despite similar systemic IgG responses. C, Titration of isotype specific ELISAs for anti-HA response showing the IgG1 dominance over IgG2a immune responses.