TY - JOUR AU - Liu, Mengyuan AU - Huang, Yi AU - Hu, Lei AU - Liu, Guoping AU - Hu, Xueping AU - Liu, Dongxu AU - Yang, Xiaosong PY - 2012 DA - 2012/09/25 TI - Selective delivery of interleukine-1 receptor antagonist to inflamed joint by albumin fusion JO - BMC Biotechnology SP - 68 VL - 12 IS - 1 AB - Interleukin-1 receptor antagonist, a cytokine that is highly therapeutic to rheumatoid arthritis and several other inflammatory diseases, exhibits rapid blood clearance and poor retention time on the target in clinical application due to its small size and lack of specificity to target tissue. Albumin has been widely employed as macromolecular carrier for drug delivery purpose to extend the plasma half-life of therapeutic molecules and has been shown to selectively accumulate and to be metabolized in the inflamed joints of patients with rheumatoid arthritis. This suggests that genetic fusion of IL-1ra to albumin can probably overcome the drawbacks of in vivo application of IL-1ra. SN - 1472-6750 UR - https://doi.org/10.1186/1472-6750-12-68 DO - 10.1186/1472-6750-12-68 ID - Liu2012 ER -