TY - JOUR AU - Dorn, Sebastian AU - Aghaallaei, Narges AU - Jung, Gerlinde AU - Bajoghli, Baubak AU - Werner, Birgit AU - Bock, Holger AU - Lindhorst, Thomas AU - Czerny, Thomas PY - 2012 DA - 2012/08/17 TI - Side chain modified peptide nucleic acids (PNA) for knock-down of six3in medaka embryos JO - BMC Biotechnology SP - 50 VL - 12 IS - 1 AB - Synthetic antisense molecules have an enormous potential for therapeutic applications in humans. The major aim of such strategies is to specifically interfere with gene function, thus modulating cellular pathways according to the therapeutic demands. Among the molecules which can block mRNA function in a sequence specific manner are peptide nucleic acids (PNA). They are highly stable and efficiently and selectively interact with RNA. However, some properties of non-modified aminoethyl glycine PNAs (aegPNA) hamper their in vivo applications. SN - 1472-6750 UR - https://doi.org/10.1186/1472-6750-12-50 DO - 10.1186/1472-6750-12-50 ID - Dorn2012 ER -