Figure 6
From: Design and development of a peptide-based adiponectin receptor agonist for cancer treatment
Anti-tumor ADP 355 activity in vivo. Orthotopic MCF-7 xenografts were established as described in Methods. After 34 days, 5 mice were treated with ADP 355 at 1 mg/kg/day dose, and 5 mice remained untreated. After 28 days, the mice were sacrificed and the lesions removed. Due to variability in tumor sizes, the largest and smallest lesions from each group were excluded from the evaluation. The excised, middle-sized lesions, from 3 treated and 3 untreated mice are shown.