Table 1 Fold changes of CYP450 isotypes' expression in three cell types after 72 h of induction with prototypic CYP450 inducers (omeprazole, dexamethasone, rifampicin, artemisinine and ethanol) over the untreated control

CYP1A1

omeprazole

50

4.05 ± 0.38*

11.13 ± 0.34*

2.09 ± 0.30

2.13 ± 0.15

dexamethasone

25

1.11 ± 0.13

19.68 ± 0.46*

3.10 ± 0.33*

12.86 ± 0.39*

CYP1A2

omeprazole

50

3.33 ± 0.14*

6.44 ± 0.80

1.67 ± 0.12

2.37 ± 0.13

dexamethasone

25

1.17 ± 0.02

13.62 ± 2.84*

3.82 ± 0.96*

5.63 ± 0.65*

CYP2B6

rifampicin

40

25.82 ± 1.30*

35.16 ± 2.76**

1.46 ± 0.10

30.70 ± 5.36**

dexamethasone

25

2.58 ± 0.72

41.49 ± 4.58**

3.98 ± 0.71*

24.25 ± 2.30*

CYP2D6

dexamethasone

25

1.26 ± 0.10

5.70 ± 1.29

2.68 ± 0.43

2.90 ± 0.73

CYP2C9

rifampicin

40

1.42 ± 0.25

15.25 ± 2.51*

2.03 ± 0.22

7.78 ± 1.82*

CYP2C19

rifampicin

40

1.87 ± 0.11

29.05 ± 2.02**

2.42 ± 0.61

19.01 ± 2.51*

CYP2C8

rifampicin

40

9.07 ± 1.03*

24.40 ± 2.48*

3.03 ± 0.62*

12.28 ± 0.81*

CYP3A4

rifampicin

40

39.43 ± 5.53**

69.50 ± 6.84**

3.64 ± 1.82*

43.29 ± 3.27**

dexamethasone

25

23.18 ± 7.25**

72.27 ± 5.64**

2.87 ± 0.96

84.10 ± 9.25**

artemisinine

50

48.18 ± 6.80**

59.28 ± 8.41**

0.89 ± 0.07

53.54 ± 1.37**

CYP2E1

ethanol

88

4.59 ± 0.53*

24.23 ± 0.41*

1.46 ± 0.19

10.74 ± 2.10*