Sustained productivity in recombinant Chinese Hamster Ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype

Table 2 List of unique differentially expressed proteins that are common between cell line pairs A and B by comparing 'Non-sustained Qp' or 'Sustained Qp' samples at Days 7&10 with Day 3 samples.

Accession no.	Gene Name	Protein name	Cell Line Pair A (Direction of expression, D7&10 v D3)	Cell Line Pair B (Direction of expression, D7&10 v D3)
*Unique to NSQp*
P18687	HSPD1	60 kDa heat shock protein, mitochondrial	Down	Down
Q13347	EIF3I	Eukaryotic translation initiation factor 3 subunit 1	Down	Down
*Unique to SQp*
P37397	CNN3	Calponin-3	Down	Down
O08782	AKR1B8	Aldose reductase-related protein 2	Down	Down

DOWN - decreased in Day 7&10 samples compared to Day 3 samples; UP - increased in Day 7&10 samples compared to Day 3 samples. Accession number is from UniProtKB/Swiss-Prot protein database. The full protein lists from each cell line pair are in Additional File 1, Table S2 (A and B).

ISSN: 1472-6750