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Table 1 List of differentially expressed proteins that are common between cell line pairs A and B by comparing all 'Non-sustained Qp (NSQp)' samples to 'Sustained Qp (SQp)' samples at days 3, 7 and 10.

From: Sustained productivity in recombinant Chinese Hamster Ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype

   

Cell Line Pair A

Cell Line Pair B

Accession no.

Gene Name

Protein Name

Direction of expression (SQp v NQp)

Direction of expression

(SQp v NQp)

Proteins differentially regulated in the same direction

O08782

AKR1B8

Aldose reductase-related protein 2

UP

UP

P07150

ANXA1

Annexin A1

DOWN

DOWN

P97429

ANXA4

Annexin A4

DOWN

DOWN

Q13347

EIF3I

Eukaryotic translation initiation factor 3 subunit 1

UP

UP

O55044

G6PD

Glucose-6-phosphate 1-dehydrogenase

DOWN

DOWN

P19378

HSPA8

Heat shock cognate 71 kDa protein

UP

UP

P14625

HSP90B1

Endoplasmin

UP, DOWN (2 spots on gel)

UP

P18687

HSPD1

60 kDa heat shock protein, mitochondrial

UP

UP

Q63525

NUDC

Nuclear migration protein nudC

DOWN

DOWN (Day 7 only)

Q9DBJ1

PGAM1

Phosphoglycerate mutase 1

UP

UP

Q9Y265

RUVBL1

RuvB-like 1

UP

UP

Proteins differentially regulated in the opposite direction

P47738

ALDH2

Aldehyde dehydrogenase, mitochondrial

UP

DOWN

P29692

EEF1D

Elongation factor 1-delta

UP

DOWN

Q9Y230

RUVBL2

RuvB-like 2

UP

DOWN

Q64303

PAK2

Serine/threonine-protein kinase PAK 2

DOWN

UP (Day 10 only)

P48500

TPI1

Triosephosphate isomerase

DOWN

UP

  1. Samples from all 3 time points were also combined into one analysis and compared. DOWN - decreased in the SQp cells compared to NSQp cells; UP - increased in SQp cells compared to NSQp cells. Accession number is from UniProtKB/Swiss-Prot protein database. The full protein lists from each cell line pair are in Additional File 1, Table S1.