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Figure 3 | BMC Biotechnology

Figure 3

From: Modification of the loops in the ligand-binding site turns avidin into a steroid-binding protein

Figure 3

Three-dimensional structure of wtAvd with the loops chosen for random mutagenesis marked. One subunit of tetrameric wtAvd with bound biotin (PDB: 2AVI) [16] is shown in the figure. The randomized amino acid residues are N12, D13, L14, G15, and S16 (shown in blue) in the loop between β-strands 1 and 2, and T35, A36, V37, and T38 (shown in purple) in the loop between β-strands 3 and 4.

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