Table 3 Relative affinities of multiple candidate biotin derivatives in mixture samples prepared via the pooling of individual compounds and SPASG.

Pooling individual compounds

Mixture A

1.4 ± 0.2

0.6 ± 0.2

1.4 ± 0.2

2.0 ± 0.5

4

Mixture B or C

1.3 ± 0.2

0.7 ± 0.3

1.4 ± 0.4

2.1 ± 0.6

6

Combinatorial syntheses

Mixture A

1.1 ± 0.3

0.6 ± 0.3

1.4 ± 0.5

2.1 ± 0.6

4

Mixture B or C

1.1 ± 0.2

0.5 ± 0.1

1.2 ± 0.3

1.9 ± 0.4

6

Homogenous methods

Pure compound

1.3 ± 0.1

0.6 ± 0.1

1.3 ± 0.1

2.0 ± 0.2

2