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Table 3 Relative affinities of multiple candidate biotin derivatives in mixture samples prepared via the pooling of individual compounds and SPASG.

From: Estimation of affinities of ligands in mixtures via magnetic recovery of target-ligand complexes and chromatographic analyses: chemometrics and an experimental model

Mixtures Compound BDEDA BBZA BCHA BNEDA n
  Mixture KX/KA KX/KA KX/KA KX/KA  
Pooling individual compounds Mixture A 1.4 ± 0.2 0.6 ± 0.2 1.4 ± 0.2 2.0 ± 0.5 4
  Mixture B or C 1.3 ± 0.2 0.7 ± 0.3 1.4 ± 0.4 2.1 ± 0.6 6
Combinatorial syntheses Mixture A 1.1 ± 0.3 0.6 ± 0.3 1.4 ± 0.5 2.1 ± 0.6 4
  Mixture B or C 1.1 ± 0.2 0.5 ± 0.1 1.2 ± 0.3 1.9 ± 0.4 6
Homogenous methods Pure compound 1.3 ± 0.1 0.6 ± 0.1 1.3 ± 0.1 2.0 ± 0.2 2