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Table 3 The leaky character of liposomal bilayers towards isoniazid from dialysis experiments.

From: Supramolecular assemblies of rifampicin and cationic bilayers: preparation, characterization and micobactericidal activity

Sample Abefore A after % Inc
ISO (0.1 mM control) 0.542 ± 0.010 0.061 ± 0.010 -
DODAB LV/ISO 0.1 mM 0.540 ± 0.010 0.052 ± 0.010 0
DODAB/DPPC 1:1/ISO 0.1 mM 0.504 ± 0.010 0.058 ± 0.010 0
ISO (10.0 mM control) 20.00 ± 0.010 0.017 ± 0.010 -
ASO MLV/ISO 10 mM 19.50 ± 0.010 0.400 ± 0.010 0.01
  1. Isoniazid incorporation in DODAB, DODAB/DPPC 1:1 or asolecithin (ASO) liposomal dispersions from ISO absorbance at 260 nm (A) before and after dialysis. Final lipid concentration was 2.0 mM.