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Table 3 The leaky character of liposomal bilayers towards isoniazid from dialysis experiments.

From: Supramolecular assemblies of rifampicin and cationic bilayers: preparation, characterization and micobactericidal activity

Sample

Abefore

A after

% Inc

ISO (0.1 mM control)

0.542 ± 0.010

0.061 ± 0.010

-

DODAB LV/ISO 0.1 mM

0.540 ± 0.010

0.052 ± 0.010

0

DODAB/DPPC 1:1/ISO 0.1 mM

0.504 ± 0.010

0.058 ± 0.010

0

ISO (10.0 mM control)

20.00 ± 0.010

0.017 ± 0.010

-

ASO MLV/ISO 10 mM

19.50 ± 0.010

0.400 ± 0.010

0.01

  1. Isoniazid incorporation in DODAB, DODAB/DPPC 1:1 or asolecithin (ASO) liposomal dispersions from ISO absorbance at 260 nm (A) before and after dialysis. Final lipid concentration was 2.0 mM.
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BMC Biotechnology

ISSN: 1472-6750

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