In situgastrointestinal protection against anthrax edema toxin by single-chain antibody fragment producing lactobacilli

Table 2 Mouse model of oral challenge by edema toxin

Oral dosage	n	Median	Minimum/maximum	Relative median weight^a(%)	P value compared to KKA317 only	P value compared to ET only
ET only	4	10.67	10.48/11.53	12.55	< 0.05^b	----
KKA317 only (negative control)	5	9.48	7.13/10.51	----	-----	< 0.05^c
KKA317 + ET	8	9.53	7.25/10.89	0.53	NS	< 0.05^c
L. paracasei pAF400 + ET	3	10.99	9.99/11.05	15.93	< 0.05^b	NS

Median (minimum and maximum) relative intestinal weight in percent total body weight upon challenge with either ET, recombinant Lactobacillus or both. ^a The difference in median of relative intestinal weight between group and negative control KKA317 in percent. ^b Represents a statistically significant difference of P< 0.05 compared with mice only receiving KKA317 using the Mann-Whitney U-test. ^c Represents a statistically significance of P< 0.05 compared with mice receiving only ET toxin using the Mann-Whitney U-test.

ISSN: 1472-6750