In situgastrointestinal protection against anthrax edema toxin by single-chain antibody fragment producing lactobacilli

Table 1 Dose study of oral challenge with edema toxin

Oral dosage	n	Median	Minimum/maximum	Relative median weight^a(%)	P value
No toxin	12	9.49	7.06/10.43	----	-----
10 μg ET	5	9.51	7.12/10.49	0.21	NS
25 μg ET	6	10.24	8.27/10.94	7.90	NS
50 μg ET	6	10.71	10.39/11.44	12.86	< 0.05^b
100 μg ET	5	10.69	10.46/11.65	11.87	< 0.05^b

Median (minimum and maximum) relative intestinal weight in percent total body weight upon challenge with increasing doses of edema toxin. ^a The difference in median of relative intestinal weight between experimental group and mice receiving no toxin in percent. ^b Represents a statistically significant difference of P< 0.05 compared with mice receiving no toxin using the Mann-Whitney U-test.

ISSN: 1472-6750