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Table 1 PTMs of mAb-1E10 detected by mass spectrometry.

From: Physicochemical and biological characterization of 1E10 Anti-Idiotype vaccine

Modifications 1E10 AF 1E10 ST
N-term glutamine to pyroglutamic acid + +
Glycosylation of Asn294 + +
Deamidation of Asn141 (heavy chain) + +
Deamidation of Asn157 (light chain) + +
Deamidation of Asn161 (light chain) + +
Oxidation of M396 + -
  1. + Modified.-Non Modified