Aggregation analysis of 1E10. HPSEC-TDA chromatograms of 1E10 ST (upper) and 1E10 AF (bottom). Refractive index (red), Log Molecular Weight (black), Right Angle Light Scattering (green) and Log Radius (pale green) signals are shown. 1E10 ST revealed one major peak corresponding to > 98% of monomers and a small amount of dimmers (< 2%). Two major peaks corresponding to > 91% monomeric 1E10 eluting and 7.9% of fragments with masses around 75 kDa were determined for 1E10 AF. Dimmers seemed to be < 1% for this mAb.