Figure 3

In vivo L19-hUG-TNFRII bio-distribution and therapy properties. A-B) Bio-distribution of the radio-iodinated L19-UG-TNFRII in F9 teratocarcinoma-bearing mice. A) The %ID/g in the tumour and in the blood at the indicated times after i.v. injection of the radio-iodinated L19-UG-TNFRII are shown (mean ± S.D.). B) The tumour to blood ratio of the %ID/g at different times after injection of the radio-iodinated protein are plotted. C) In vivo therapy experiments with L19-UG-TNFRII in CAIA animal models. The median arthritis scores determined in treated and control mice at day 3 to 10 from the injection of anti-collagen antibodies are indicated. The p values determined using the non parametric Mann-Whitney U test are indicated. Bars indicate the standard error of the mean.