Figure 1

Protein sequence alignment of A. nidulans CreB and the putative T. reesei orthologue. Black box denotes identical amino acids. Grey box denotes similar amino acids. Solid underline denotes the ubiquitin hydrolayse domain, Asp⁵⁴ to Tyr⁴⁷⁴. The position of insertion of the A. nidulans amdS region is indicated, between Tyr⁴²⁵ and His⁴²⁶. Arrows denote the active sites, His⁴²⁸ and Asp⁴³⁷ of the ubiquitin hydrolase domain [26].