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Table 5 PNA Glu-Oct6-13410a Induced Apoptosis in DU-145 and PANC-1 Cells

From: Creation of a novel peptide with enhanced nuclear localization in prostate and pancreatic cancer cell lines

DU-145

nM PNA

0

300

600

1000

13410a

% apop.

0.05

8.7

48.7*

82.5*

2.9

SD

0.04

7.7

24.1

5.9

4.6

PANC-1

nM PNA

0

300

600

1000

13410a

% apop.

0.3

17.4

69.6*

84.6*

1.1

SD

0.2

14.6

5.9

14.6

0.8

  1. Cells were incubated with PNAs Glu-Oct6-13410a or 13410a for 48 hr, at which time they were harvested and stained with FITC-annexin V plus PI, then apoptosis was quantified by flow cytometry. PNA 13410a was added at 1000 nM. The percents apoptosis are the means of 3 experiments; SD = standard deviation.
  2. * p < 0.01 by repeated ANOVA
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BMC Biotechnology

ISSN: 1472-6750

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