Skip to main content
Figure 1 | BMC Biotechnology

Figure 1

From: Characterization of a molecular switch system that regulates gene expression in mammalian cells through a small molecule

Figure 1

Dose Response Curves for RXR Variants. (A) Dose response curves for the activation of wild-type RXR DBD and LDB (RXRwt) and RXR variant Q275C;I310M;F313I with RXR DBD (QCIMFI) in response to 9cRA and LG335. Activity is measured in relative light units (RLU) derived from the measurement of luciferase activity and normalization against a β-galactosidase internal standard. Basal activity is around 20 RLUs. (B) Fold inductions of RXRwt and QCIMFI in the presence of various LG335 concentrations.

Back to article page