Figure 6

The effects of rFGF21 on reducing plasma glucose in diabetic rats. The STZ treated diabetic rats were injected with different doses of rFGF21 once daily for two weeks. Control: 0.9% NaCl; Low: 0.15 mg/kg rFGF21; Medium: 0.3 mg/kg rFGF21; High: 0.6 mg/kg rFGF21; Insulin: 5U per rat. The results show that rFGF21 acts in a dose-dependent manner to reduce plasma glucose in diabetic rats, with the high dose rFGF21 demonstrating better effects than the other doses. Compared to rFGF21, insulin displays a more significant effect in decreasing plasma glucose. ^aP < 0.05, ^bP < 0.01 and ^cP < 0.001 were considered as the significant difference for post-treatment compared to pre-treatment.